Anabolic effects of a novel simvastatin derivative on treating rat bone defects

HIGHLIGHTS

• who: Tien-Ching Lee et al. from the Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan have published the research work: Anabolic Effects of a Novel Simvastatin Derivative on Treating Rat Bone Defects, in the Journal: Biomedicines 2022, 10, x FOR PEER REVIEW of /2022/
• what: We used calvarial and femoral long-bone defect models to reveal the anabolic effect of local KMUHC-01 and revealed that KMUHC-01 enhanced the BMP-2 protein level in repaired bone and accelerated de novo bone formation while increasing mechanical properties in the bone . . .
  

   

  

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