Assessment of in silico and in vitro selpercatinib metabolic stability in human liver microsomes using a validated lc-ms/ms method

HIGHLIGHTS

• who: Mohamed W. Attwa and colleagues from the Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia have published the article: Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method, in the Journal: Molecules 2023, 2618 of /2023/
• what: In the current experiment a highly specific sensitive and fast liquid chromatography tandem mass spectrometry (LC-MS/MS) for quantifying SLP in human liver microsomes (HLMs) was developed and applied to the metabolic stability evaluation of SLP.
• how . . .
  

   

  

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