HIGHLIGHTS
- who: Posted Date January and collaborators from the Icahn School of Medicine at Mount Sinai have published the paper: Inufffdammasome mediated neuronal-microglial crosstalk: a therapeutic substrate of the familial C9orf72 variant of frontotemporal dementia/amyotrophic lateral sclerosis, in the Journal: (JOURNAL)
- what: The study provides evidence linking inflammasome activation to neurodegeneration and provides a basis for the investigation of innate immune inflammasome inhibitors as a treatment of disease in c9FTD/ALS. Ultimately, the authors demonstrate that by targeting microglial reactivity through inflammasome inhibition, FTD/ALS pathogenesis was significantly attenuated through the genetic ablation of . . .
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