HIGHLIGHTS
- who: Xinyu Wang from the DepartmentJilin University Radiotherapy, China-Japan have published the article: Cyclophilin A contributes to shikonin-induced glioma cell necroptosis and promotion of chromatinolysis, in the Journal: Scientific Reports Scientific Reports
- how: Cells in the mid-log phase were used in the experiments. These results indicated that CypA accounted for shikonin-induced mitochondria damage. These data indicated that CypA increased intracellular ROS via causing overproduction of mitochondrial superoxide.
SUMMARY
Human U87, U251, U373, SHG44 and rat C6 glioma cells were all obtained from Shanghai Institute of Cell Biology . . .
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