HIGHLIGHTS
SUMMARY
Thrombosis occurs due to an imbalance between procoagulant, anticoagulant, and fibrinolytic systems activation. The reported incidence of thrombotic events in children varied in clinical studies, ranging between 0.07-0.14/10,000 in all patients and 58/10,000 in pediatric patients who underwent potentially thrombogenic procedures. Summarizing recommendations from guidelines and key findings from analyzed clinical trials in pediatric patients with acute VTE heparin therapy should be initiated and continued for at least five days. Although OAT with VKAs could be instituted after heparin therapy, clinical studies highlighted that some DOACs were . . .
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