Timosaponin a3 inhibits palmitate and stearate through suppression of srebp-1 in pancreatic cancer

HIGHLIGHTS

• who: Yumi Kim et al. from the College of Korean Medicine, Kyung Hee University, Kyungheedae-ro have published the research work: Timosaponin A3 Inhibits Palmitate and Stearate through Suppression of SREBP-1 in Pancreatic Cancer, in the Journal: Pharmaceutics 2022, 14, 945. of 14/02/2019
• what: The authors aimed to explore the key molecular mechanisms underlying the growth inhibitory effects of TA3 using PC cells and xenograft model. The study demonstrated that SREBP-1 was key transcription factor involved in pancreatic cancer growth and it remained precursor form due to TA3 reducing the adipogenesis . . .
  

   

  

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