Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia

HIGHLIGHTS

• who: Eleanor L. Woodward from the WGS data analysis and identification of BTRI and B/ATRI mutations WGS data from , BCP ALL cases have been previously published The initial putative somatic mutations were identified by the Complete Genomics Cancer Sequencing pipeline and the data were further filtered for Somatic Score u2265, and number of unique reads for the mutated allele >10. For Complete Genomics data generated by the TARGET program (n=34), somatic variants were identified by the TARGET WGS analysis pipeline ([https://ocg.cancer.gov/programs/ target/target-methods#3233]). Illumina WGS sequencing libraries of nineteen . . .
  

   

  

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