Synthesis and biological evaluation of substituted acetamide derivatives as potential butyrylcholinestrase inhibitors

HIGHLIGHTS

• who: Dehong Yu from the SchoolSichuan University have published the research work: Synthesis and biological evaluation of substituted acetamide derivatives as potential butyrylcholinestrase inhibitors, in the Journal: Scientific Reports Scientific Reports of 20/Oct/2022
• how: Compared with the characteristics of galantamine and tacrine the data indicated that 8c also had a high binding capacity to human serum protein and adequate clog P low levels of primary metabolites and a good Caco-2 permeability.

SUMMARY

According to the binding mode of 970180 with ­BChE17, its indole moiety extended in the choline . . .

 



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