HIGHLIGHTS
- who: Jaiprakash Sharma from the (UNIVERSITY) have published the article: Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination, in the Journal: (JOURNAL)
- what: The authors show that calpains are regulated by a cytosolic protein of previously uncharacterized function whose pathogenic mutations result in epilepsy progressive ataxia and severe neurocognitive deterioration. The authors show that works in with Cullin-3 and Rbx1 to execute atypical nondegradative ubiquitination of calpains at specific sites (K398 of calpain 1 and K280 and K674 of calpain 2). By using proteomics and cell biology . . .
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