HIGHLIGHTS
SUMMARY
None of these biomarkers are widely used in clinical practices, and the function of these candidate signatures still lacks validation in well-designed large-scale studies (Rybarczyk-Kasiuchnicz et_al, 2021). The vast majority of cancer-related deaths, such as hepatocellular carcinoma and breast cancer (Saxena et_al, 2021; Gao et_al, 2022), are due to metastatic spread of cancer cells, a process aided by epithelial-mesenchymal transition (EMT) (Atay, 2020; Kitz et_al, 2021). EMT also plays a very important role in the malignant evolution and migration capacities of tumors (Pastushenko and Blanpain, 2019; Xu et_al, 2020a . . .
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