HIGHLIGHTS
- who: Sonali Narang from the 0016, USA have published the Article: NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization, in the Journal: (JOURNAL)
- what: The authors investigate the role 3D genome organization plays in EK-mediated relapse. The authors assessed changes in these three cell lines from NSD2 Low (knockdown) to NSD2 High (mutant) as NSD2 EK is a relapse-enriched mutation in patients and results in the overactive form of NSD2. The authors show that NSD2 EK plays an essential role in reorganizing the 3D genome through a . . .
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