HIGHLIGHTS
SUMMARY
In recent years, and there is substantial evidence that both the dysfunction of mitochondrial metabolism and ROS are associated with immune_response. Analysis of TME immune cell infiltration and the immune_response predictor ssGSEA (single sample gene set enrichment analysis), EPIC, xCELL, and MCPcounter algorithms were performed to quantify the relative abundance of TME immune cell infiltration as well as assess the immune function in the CRC patients. The authors hypothesized that the abundant stromal component in COPcluster C1 and C2 inhibited potential antitumor immune_response. TIDE, a newly frontiersin.org 10.3389/fimmu.2023.1165101 score . . .
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