Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles

HIGHLIGHTS

  • who: Sabha Asghar from the Immunology, BioPharmaceuticals RandD, Cambridge, UK have published the article: Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles, in the Journal: (JOURNAL)
  • what: The authors aimed to characterise and profile sEVs from normal human bronchial epithelial_cells (NHBEs) and IPF-diseased human bronchial epithelial_cells (DHBEs) and determine the effect of potentially regulatory RNA content on NHBEs and healthy air-liquid interface (ALI) cultures. Within this study, the authors demonstrate the potential for sEVs from DHBEs to drive senescence in surrounding cells. Similarly, this study has confirmed that DHBEs . . .

     

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