HIGHLIGHTS
SUMMARY
Since relatively little is known about the antidermatophyte activity of AzA, the authors investigated for the first time its in_vitro and in_vivo effects on dermatophyte species in comparison with its nano transethosomal formulation (AzA-TEs) and itraconazole as a positive control. Two guinea pig models are performed in the in_vivo study of AzA-TEs. The antidermatophyte activity of the optimized AzA-TEs formulation was evaluated both in_vitro and in_vivo. The selected formula was further characterized and investigated ble residual error was obtained indicating the validity of the model for the preparation of both in_vitro . . .
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