Analyses of thymocyte commitment to regulatory t cell lineage in thymus of healthy subjects and patients with 22q11.2 deletion syndrome

HIGHLIGHTS

• who: Simon Borna and collaborators from the Heinrich Heine University of Du00fcsseldorf, Germany have published the Article: Analyses of thymocyte commitment to regulatory T cell lineage in thymus of healthy subjects and patients with 22q11.2 deletion syndrome, in the Journal: (JOURNAL)
• what: The authors report that CD3+CD4+CD8+ CD25+FOXP3+ cells are the first intrathymic cell subset with fully demethylated TSDR, indicating that this is the first stage with detectable Treg cell lineage commitment. The expression of FOXP3 and CD25, and the TSDR demethylation occur simultaneously during T_cell development in mature double positive . . .
  

   

  

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