HIGHLIGHTS
SUMMARY
Using two structurally unrelated CCR1-specific antagonists the authors show that CCR1 is necessary for TAM activation of glioma invasion in-vitro. The authors show that mRNA for CCR1 and CCR1 ligands, including CCL3, are strongly upregulated in a microglial cell line treated with glioma conditioned media. The observation that GL261 do not express CCL3 and that CCR1 is upregulated in MG cells at after to GL261-CM this cells hypothesis. once they accumulate theexposure tumor. For most assays, to maintain constant cell numbers, cells were plated at a density per invasion chamber of . . .
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