Enzymatic reactions of ago4 in rna-directed dna methylation: sirna duplex loading, passenger strand elimination, target rna slicing, and sliced target retention

HIGHLIGHTS

• who: ARGONAUTE, and RNA polymerase, V] from the Department Indiana University have published the research: Enzymatic reactions of AGO4 in RNA-directed DNA methylation: siRNA duplex loading, passenger strand elimination, target RNA slicing, and sliced target retention, in the Journal: (JOURNAL)
• what: The authors show that 23-nt RNAs function as passenger strands during 24-nt siRNA incorporation into AGO4. The authors propose that siRNA passenger strand elimination and AGO4 tethering to sliced target RNAs are distinct modes by which AGO4 slicing enhances RNA-directed DNA methylation. [ Using genetic and genomic approaches, as well as . . .
  

   

  

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