Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

HIGHLIGHTS

SUMMARY

For most important class of drug_targets, genetic evidence needs to be generalizable to diverse populations. Circulating proteins, as representatives of intermediate molecular phenotypes in human health, are widely used to reveal novel drug_targets and translational biomarkers for clinical outcomes1. In recent years, studies of blood-based protein quantitative trait loci (pQTL) using aptamer-based multiplex protein assay (SOMAscan) and antibody-based multiplex immunoassays (Olink panels) have identified thousands of associations between single-nucleotide polymorphisms (SNP) and protein levels, many of which colocalized with association signals for common human diseases2-12. Complementary GWAS analysis based . . .

 



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