HIGHLIGHTS
- who: Freedy and Ally Maria from the Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA have published the research: Drug addiction mutations unveil a repressive methylation ceiling in EZH2-mutant lymphoma, in the Journal: (JOURNAL)
- what: Exploiting this vulnerability the authors show that inhibition of SETD2 induces H3K27me3 spreading and blocks lymphoma growth. Through the discovery and mechanistic study of drug addiction mutations that hyperactivate PRC2, here the authors show that not only lower but also upper thresholds exist for the repressive PRC2 mark, H3K27me3, in EZH2-mutant DLBCL cells. The authors . . .
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