Ppar- γ activation alleviates osteoarthritis through both the nrf2/nlrp3 and pgc-1 α / δψ pathways by inhibiting pyroptosis

HIGHLIGHTS

• who: Zhencheng Feng and collaborators from the Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China have published the Article: PPAR- u03b3 Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1 u03b1 / u0394u03c8 Pathways by Inhibiting Pyroptosis, in the Journal: PPAR Research of 27/03/2023
• how: As expected the ELISA results showed that IL-1u03b2 and IL-18 levels in the cartilage increased significantly in the OA group . The MTS assay results showed that 0 0.5 and 1 u03bcg/ml LPS exhibited a dose-dependent inhibition on cell viability . . .
  

   

  

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