Age-related methylation changes in the human sperm epigenome

HIGHLIGHTS

• who: Olga Krasnova from the Institute of Human Genetics, Julius Maximilians University, Wu00fcrzburg, Germany have published the article: Age-related methylation changes in the human sperm epigenome, in the Journal: (JOURNAL)
• what: The authors show a species-specific effect of paternal age on HSA19, which has not been conserved in the marmoset. Although the underlying mechanism(s) remains unclear, the authors propose that due to nucleosome retention and/or sperm chromatin packaging loci, sperm ageDMRs are more susceptible to defects in the maintenance of methylation patterns with increasing age.
• how: To further corroborate . . .
  

   

  

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