Structural basis of ty1 integrase tethering to rna polymerase iii for targeted retrotransposon integration

HIGHLIGHTS

• who: Phong Quoc Nguyen from the (UNIVERSITY) have published the research work: Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration, in the Journal: (JOURNAL)
• what: The authors report cryo-EM structures of Pol III in complex with IN1, revealing a 16-residue segment at the IN1 C-terminus that contacts Pol III subunits AC40 and AC19, an interaction that the authors validate by in_vivo mutational analysis. The authors show that IN1 binding associates with reordering of different Pol III regions that are distant from the IN1 binding_site.
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