HIGHLIGHTS
- who: . et al. from the University of Alabama at Birmingham, United States have published the Article: Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment, in the Journal: (JOURNAL)
- what: In fact, recent studies showed the importance of targeting CAFs and stroma interactions to overcome drug resistance in MM. Here, the authors provide proof-ofconcept data that demonstrate a previously unappreciated metabolic MM-BMSCs network in which indirect co-culture induces metabolic reprogramming and drug resistance-like metabolism in MM cells.
SUMMARY
Altered metabolic pathways in MM cells (A . . .
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