HIGHLIGHTS
- who: Elena Shanina from the (UNIVERSITY) have published the research: Targeting undruggable carbohydrate recognition sites through focused fragment library design, in the Journal: (JOURNAL)
- what: The authors show the effect of MBPs on the clinically relevant lectins DC-SIGN, Langerin, LecA and LecB. The authors show that metal-dependent lectins are more druggable than previously anticipated. Taken together, the authors report the first evidence of hydroxamates targeting carbohydrate-protein interactions. To prove the utility of a target-oriented MBP-FBDD approach, the authors aimed to unravel its interactions with lectins having one, two, and three . . .
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