Decitabine priming increases anti-pd-1 antitumor efficacy by promoting cd8+ progenitor exhausted t_cell expansion in tumor models

HIGHLIGHTS

  • who: Xiang Li and collaborators from the Departmente of Health Service and Transfusion Medicine, Beijing, China have published the Article: Decitabine priming increases anti-PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T_cell expansion in tumor models, in the Journal: (JOURNAL)
  • what: The authors show that low-dose combination therapy of decitabine plus anti-PD-1 markedly improved the magnitude and functionality of the clonally expanded progenitor Tex subset and displayed robust antitumor potency. Since the authors focused on CD8+ cells, the authors selected cells in clusters 2, 5, and 7 (a total of . . .

     

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