HIGHLIGHTS
- who: Matthew J. Wiest and collaborators from the Biomedica (IRIB) (CNR), Italy University Hospital Dusseldorf, Germany have published the research: Disruption of endosomal trafficking with EGA alters TLR9 cytokine response in human plasmacytoid dendritic cells, in the Journal: (JOURNAL)
- what: This study reports that, EGA, an endosomal trafficking inhibitor, can diminish the expression of both IFNa and proinflammatory cytokine by TLR9-activated pDCs from the blood of healthy donors. This study has extended these findings by investigating how pDCs respond to different types of nucleic_acid ligands in the presence and absence of the endosome trafficking . . .
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