HIGHLIGHTS
- who: Asparagine protects pericentral hepatocytes and colleagues from the Institut Fu00e9du00e9rale de Lausanne, Lausanne, Switzerland have published the article: injury, in the Journal: (JOURNAL)
- what: The authors demonstrate that a pericentral enzyme, asparagine synthetase (ASNS), colocalizes with GLUL and converts its main product, glutamine, into asparagine. The authors show that during acute liver injury, pericentrally expressed ASNS is highly induced through the enhanced recruitment of the nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) to its promoter region. This study shows that induction of ASNS in pericentral hepatocytes through a noncanonical, LRH-1-mediated . . .
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