Large-conductance ca2+-activated k+ channel β1-subunit maintains the contractile phenotype of vascular smooth muscle cells

HIGHLIGHTS

  • who: Meili Wang from the United States University of Rochester Medical have published the research: Large-conductance Ca2+-activated K+ channel u03b21-subunit maintains the contractile phenotype of vascular smooth muscle cells, in the Journal: (JOURNAL)
  • what: Taken together, this study demonstrated that BKCa -u03b21 is an important regulator of VSMC identity by preventing its phenotype switching.
  • how: These results indicated that BKCa u03b21 downregulation was correlated with the changes of VSMC contractile phenotype markers (u03b1-SMA and SM22u03b1). markers indicating the transformation from differentiated to dedifferentiated phenotype. The data indicated that BKCa . . .

     

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