T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

HIGHLIGHTS

• who: Venetia Bazioti from the University Medical Groningen, AV Groningen, the Netherlands have published the Article: T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 28/05/2021
• what: The authors show that combined T_cell Abca1/Abcg1 deficiency, which induces T_cell cholesterol and cholesteryl ester (CE) accumulation by ~2.5-fold, decreases peripheral T_cell numbers, and induces T_cell activation and T_cell apoptosis in wild-type 2 and Ldlr-/- mice. The studies have shown that T_cell Abca1/Abcg1 deficiency increased plasma_membrane cholesterol . . .
  

   

  

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