HIGHLIGHTS
- who: Valentina Buemi from the Centre have published the article: TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that 2,2,7trimethylguanosine (TMG) capping of the human telomerase RNA by the CB protein trimethylguanosine synthase 1 (TGS1) drives telomerase-based TMM by suppressing exonuclease-1 (EXO1)-dependent formation of recombinogenic telomere substrates that fuel the ALT pathway. The authors show that TGS1-mediated 2,2,7-TMG cap formation at the 5u2032end of . . .
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