The role of disordered regions in orchestrating the properties of multidomain proteins: the sars-cov-2 nucleocapsid protein and its interaction with enoxaparin

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SUMMARY

    The study of the interaction of N with molecules that mimic nucleic_acids` charge, such as polyanions, can thus help to elucidate one of the key driving forces responsible for its function, electrostatic contribution. The authors focused on the N-terminal region of the protein using a construct that comprises residues 1-248 (IDR1-NTD-IDR2, referred to as NTR), and on the NTD construct, (residues 44-180). All the peaks that belong to this region characterized byand the are residues in the complex almost all "disorder-promoting" amino_acids, with a large disappear upon the . . .

     

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