Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound

HIGHLIGHTS

  • who: Yiming Guo from the EU EU have published the paper: Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound, in the Journal: (JOURNAL) of 13/05/2022
  • what: As an alternative, the authors focused on the more recently identified and highly homologous bacterial VAO-type oxidase: EUGO from Rhodococcus jostii RHA126. The structural coordinates generated in this study have been deposited in the Protein Data Bank under accession codes: 7YWU and 7YWV.
  • how: Engineering a thermostable EUGO variant by computational predictions Before tuning the activity . . .

     

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