Fhl2 deficiency impairs follicular development and fertility by attenuating egf/egfr/yap signaling in ovarian granulosa cells

HIGHLIGHTS

• who: Chen Wang from the [7, , ], and , deficiency decreased follicular development and fertility, it seems that , may play bidirectional roles in ovarian physiologyBalanced , expression level is critical to maintain the normal ovarian physiology and female fertility. In conclusion, our present study demonstrated that , deficiency inhibited GCs proliferation, impaired female mice follicular development and fertility. , depletion also impaired EGFR and Hippo/YAP signaling in GCs. Mechanistically, regulated Egf and Egfr transcription via binding with transcriptional factors. EGF in turn, not only induced , expression and nuclear accumulation, but also stimulated , activation and expression. Collectively, our study provide evidence that . . .
  

   

  

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