HIGHLIGHTS
SUMMARY
Published maps and institutional affil- Tau is an abundant central nervous system (CNS) protein, largely localized on the labile domains of microtubules, promoting their elongation and thus regulation of axonal transport. Alternative splicing of the primary_transcript from the single human MAPT gene on chromosome 17 gives rise to 6 tau isoforms in the adult CNS and two isoforms in the peripheral nervous system. In contrast, all isoforms are expressed in the adult CNS with almost an equimolar ratio of 3R to 4R species. 2N isoforms show a higher propensity for somatodendritic localization, while 1N . . .
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