HIGHLIGHTS
- who: Alice H. Grant and collaborators from the Department of Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA have published the research work: JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling, in the Journal: (JOURNAL)
- what: In agreement with earlier reports , the authors demonstrate that inactive JAK1 JH1 and JH2 mutants can prevent IL-2-induced activation of STAT5 .
- future: Studies on this interface are needed to exploit mechanisms of allosteric inhibition and provide new avenues for drug discovery efforts of JAK inhibition.
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