Pioneer factor ascl1 cooperates with the mswi/snf complex at distal regulatory elements to regulate human neural differentiation

HIGHLIGHTS

SUMMARY

Differential gene_expression analysis confirmed the transitional progenitor cluster is uniquely enriched for ASCL1 (Fig 1F,G), with low-level expression also found in a subset of cycling progenitors. Using cluster label transfer, the authors show that cell states present in_vivo map to clusters in the in_vitro system. Not only are the cell states found in_vitro similar to known cell states in_vivo, but also the order of developmental stages in_vitro follows the expected developmental path observed in_vivo (Supplemental Fig S1F). The fetal scRNA-seq clusters with highest correlation to in_vitro transitional progenitors in terms of . . .

 



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