HIGHLIGHTS
- who: Huqiao Luo and colleagues from the Division have published the paper: NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development, in the Journal: (JOURNAL)
- what: The authors aimed to identify the key immune cell type(s) and cellular mechanisms driving lupus pathogenesis under the condition of NCF1-dependent ROS deficiency. Using cell-specific Cre-deleter human NCF1-339 variant knockin and transgenic mouse strains the authors show that low ROS production in plasmacytoid dendritic cells (pDCs) exacerbated both pristane-induced lupus and a potentially new Y-linked autoimmune accelerating . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.