Design, synthesis, and bioassay of 2`-modified kanamycin a

HIGHLIGHTS

• who: Ribai Yan and collaborators from the Peking University, Beijing, China have published the article: Design, Synthesis, and Bioassay of 2`-Modified Kanamycin A, in the Journal: Molecules 2022, 27, 7482. of /2022/
• what: The study provided valuable structure-activity relationship information which would help researchers to develop new aminoglycoside antibiotics more effectively. The authors report a modifying strategy for kanamycin based on the structural information.
• future: In recent years some 3D structures of A Site in complex with aminoglycosides have been disclosed which affords a brand-new perspective to explain such a . . .
  

   

  

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