Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility

HIGHLIGHTS

  • who: Peyton J. Spreacker from the (UNIVERSITY) have published the research: Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility, in the Journal: (JOURNAL) of 21/07/2022
  • what: The authors show EmrE does confer susceptibility to several previously uncharacterized small-molecule substrates in E. coli, including harmane. The authors focus on the biological implications of alternative transport modes and whether it is possible to not just inhibit multidrug resistance efflux pumps to suppress their contribution to antibiotic resistance, but rather activate alternative transport modes that would be detrimental to . . .

     

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