HIGHLIGHTS
- who: Nicholas J. MacDonald from the (UNIVERSITY) have published the article: Structural and immunological differences in Plasmodium falciparum sexual stage transmission-blocking vaccines comprised of Pfs25-EPA nanoparticles, in the Journal: (JOURNAL)
- what: Published in partnership with the Sealy Institute for Vaccine Sciences Here the authors report full biochemical and biophysical characterization of Pfs25M and Pfs25M-EPA, including Pfs25M crystallization in complex with a Fab of the transmission-blocking antibody, 1G2. The authors demonstrate that different protein modifications impacted the 1) binding of two transmission-blocking monoclonal_antibodies (mAbs) against the monomeric proteins, and 2) specificity . . .
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