Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and fcgr2a genotype

HIGHLIGHTS

  • who: MacIntosh G. Cornwell from the (UNIVERSITY) have published the research work: Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype, in the Journal: (JOURNAL)
  • what: Next, using Weighted Gene Co-expression Network Analysis (WGCNA), the authors aimed to reduce the genes down to a set of co-regulated modules to explore for specific signals that would be consistent across the SLE population, and to find signals with higher variance within the heterogenous population. The analysis demonstrates that genes that are highly expressed in SLE vs controls and . . .

     

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