HIGHLIGHTS
SUMMARY
Duncan et_al subsequently described two patients from the same family with a homozygous STAT2 mutation specifically affecting this negative_feedback regulatory role of STAT2. Shortly thereafter, Gruber et_al identified another patient with a mutation involving the same amino_acid residue of STAT2. Lentiviruses were produced by co-transfection of pCMVVSV-G (Addgene plasmid no. 8454), psPAX2 (Addgene plasmid no. 12260), and lentiviral transfer plasmid (pHRSIN-CSGW-STAT2 WT, pHR-SIN-CSGW-STAT2 p.(A219V), or pHR-SIN-CSGW-STAT2 p.(R148W)) in HEK 293FT_cells using Lipofectamine 2000 Transfection Reagent (11,668,019, Invitrogen,). The p.(A219V . . .
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