Low number of neurosecretory vesicles in neuroblastoma impairs massive catecholamine release and prevents hypertension

HIGHLIGHTS

  • who: Annick Mu00fchlethaler-Mottet and collaborators from the University Hospital Carl Gustav Carus, Germany have published the Article: Low number of neurosecretory vesicles in neuroblastoma impairs massive catecholamine release and prevents hypertension, in the Journal: (JOURNAL)
  • what: The authors aim to provide a detailed comparison of the biosynthesis, metabolism and storage of catecholamines and metanephrines between patients with NB and PHEO. The authors explore the metabolism of CATs in NB versus PHEO/PGL and decipher at the molecular level the mechanism that prevents NB from inducing hypertension, an expected clinical sign for a CAT-producing . . .

     

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