Cd1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses

HIGHLIGHTS

• who: Phillip M. Brailey from the (UNIVERSITY) have published the article: CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses, in the Journal: (JOURNAL) of 27/Oct/2022
• what: The authors show that CD1ddeficient macrophages exhibit a metabolic reprogramming, with a downregulation of lipid metabolic pathways and an increase in exogenous lipid import. In line with this model, the authors propose that the metabolic rewiring induced by the lack of CD1d, primes cells for hyper-responsiveness to TLR ligands.
• how: The authors explored the function of CD1d in inflammatory responses . . .
  

   

  

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