Enhanced nsaids solubility in drug-drug formulations with ciprofloxacin “2279

HIGHLIGHTS

SUMMARY

    Although the combination of NSAIDs and CIP is generally regarded as safe, it should be noted that there have been several reports suggesting an increased risk of CIP side effects affecting the central nervous system when CIP is administered along with certain NSAIDs, such as ibuprofen. Only two salt structures containing CIP and a NSAID as counterion have been reported: CIP-indoprofen monohydrate and CIP- diflunisal salts. Synthesis of CIP-MEF·H2 O, CIP-TLF, CIP-SLD, CIP-KET, and CIP-DKT salts: mixtures of CIP (0.2 mmol, 66.27 mg) and the . . .

     

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