High-resolution nanopore methylome-maps reveal random hyper-methylation at cpg-poor regions as driver of chemoresistance in leukemias

HIGHLIGHTS

• who: Alberto Magi from the University of Florence, Florence, Italy have published the research: High-resolution Nanopore methylome-maps reveal random hyper-methylation at CpG-poor regions as driver of chemoresistance in leukemias, in the Journal: (JOURNAL) of 15/Nov/2022
• how: This approach however is suboptimal for the of long-read data which are instead characterized by large low-density CpG regions alternated with small high density CpG thus developed a novel tool (PoreMeth) based a heterogeneous form of the shifting level model (SLM)25 which integrates distances between consecutive in the segmentation algorithm . . .
  

   

  

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