Single cell transcriptomic analysis of hpv16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer

HIGHLIGHTS

  • who: Mary C. Bedard from the , have published the research: Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer, in the Journal: (JOURNAL) of 21/03/2022
  • what: Altogether, the authors show enrichment of HIDDEN cell biomarkers in patient-derived 3D in_vitro models of cutaneous, cervical, and tonsillar epithelium, as well as in HPV-driven premalignant and malignant patient biopsies that reflect stages of cancer evolution. candidates to suppress the HIDDEN cells and eliminated consideration for further mechanistic studies.
  • how: ScRNAseq reveals enrichment of distinct keratinocyte subpopulations . . .

     

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