Design of novel enantiopure dispirooxindolopyrrolidine-piperidones as promising candidates toward covid-19: asymmetric synthesis, crystal structure and in silico studies

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  • who: Amani Toumi et al. from the Laboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR ES39), Department of Chemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation have published the research work: Design of Novel Enantiopure Dispirooxindolopyrrolidine-Piperidones as Promising Candidates toward COVID-19: Asymmetric Synthesis, Crystal Structure and In Silico Studies, in the Journal: Molecules 2022, 27, 3945. of 28/05/2022
  • what: In this study the ability of a small library of enantiomerically pure spirooxindolopyrrolidine-grafted to inhibit the main protease of SARS-CoV-2 (Mpro . . .

     

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