HIGHLIGHTS
SUMMARY
Multiple_sclerosis (MS) is a chronic inflammatory neurodegenerative disease affecting over two million people around the world. Previous studies have found more abundant CSF NfL in MS patients than in sex- and age-matched controls and suggested that CSF NfL may help distinguish MS subtypes. With the increasing evidence of blood NfL measurements in MS patients, the authors performed the present systematic review and meta-analysis to evaluate the value of blood NfL in diagnosing MS, distinguishing MS subtypes and severity, and predicting disease worsening. Inclusion and exclusion criteria All eligible studies should meet the . . .
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