Fibroblast a20 governs fibrosis susceptibility and its repression by dream promotes fibrosis in multiple organs

HIGHLIGHTS

• who: Wenxia Wang from the Human subjects Subjects with SSc, SSc-ILD, and healthy volunteers were recruited from the Northwestern Scleroderma Program and the University of Pittsburgh School of MedicineAll patients fulfilled ACR criteria for the classification of SSc. Forearm skin biopsies were performed following obtaining written informed consent and in accordance with protocols approved by the Institutional Review Board for Human Studies at Northwestern University and lung transplant biopsies from the University of Pittsburgh School of Medicine. Lung tissues were obtained from SSc patients undergoing lung transplantation at the University of Pittsburgh Medical Center. Normal lung . . .
  

   

  

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